When the Indianapolis Colts march into Nashville to face the Tennessee Titans this Sunday (1:00 PM ET), Week 3 of the 2025 NFL season will deliver its first true AFC South showdown—a divisional clash that could set an early tone for the race. Both teams enter this matchup hungry to prove their mettle, with the Colts looking to build momentum in a season where every divisional win could be the difference between playoff contention and disappointment. Meanwhile, the Titans will aim to defend their home turf in what promises to be a physical, hard-fought battle between two rivals who know each other all too well.

The stakes are simple: bragging rights, divisional positioning, and the chance to stake a claim as the South’s team to beat. With no room for error in a league where parity reigns, this game isn’t just about X’s and O’s—it’s about which squad can impose its will when the pads start popping. For fans, it’s a must-watch collision of two franchises with everything to gain and even more to lose.