The NFL's most heated rivalry reignites in Week 1 as the San Francisco 49ers storm into Lumen Field to face the Seattle Seahawks in a Sunday afternoon showdown (4:05 PM ET) that promises to set the tone for both teams' 2025 campaigns. This isn't just another season opener—it's a clash between two NFC West powerhouses with bad blood dating back a decade, where every snap carries playoff implications before the leaves even turn. Seattle's raucous 12th Man will be at full throat for this one, eager to remind the 49ers that the Pacific Northwest remains hostile territory despite San Francisco's recent division dominance.

With both squads entering uncharted territory under new offensive schemes and revamped rosters, this game becomes a high-stakes litmus test. The 49ers will look to establish their physical brand early, while Seattle's defense—always opportunistic at home—will aim to force turnovers and swing momentum in front of their frenzied crowd. In a league where Week 1 often separates contenders from pretenders, this border battle isn't just about bragging rights—it's about sending an opening statement to the entire NFC that could echo through December.